it does make a difference but we don’t live in an ideal world… I like a system that can cope in a living room sized space…but then introduce that into a smaller slightly dampened room and its other level stuff with the micro/macro dynamics you get..
It is the speaker/room interaction that creates problems. And to a lesser degree one could add amplification (amplifier/speaker interaction may result in "boomy"/uncontrolled bass).
The room is responsible below the Schroeder frequency (~200-400Hz) and the speaker takes over above that.
Room size and proportions, surface materials and furnishings all have a huge influence in the end result.
Woofer distance to boundaries (walls, floor, ceiling) and listening spot location will determine the impact of the room in the bass and sub-bass region.
Speaker directivity and toe-in, proximity to side walls and their surface materials will affect the midrange and treble.
This is the response of my speakers in two different homes, almost identical above 500Hz:
• the "lossier"
old room has underlay-carpeted beam and block floor, plasterboard to timber upper-floor ceiling and plasterboard on stud walls
• the denser-construction
new room has carpet on concrete slab floor, plaster on concrete slab, plaster on block walls